Unwanted side effects that usually will not call for clinical interest (report back to your health care provider or well being care Specialist if they go on or are bothersome):
cyclophosphamide will raise the amount or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.
What's more, the purportedly “reduced” abuse prospective of modafinil only relates to circumstances during which it really is remaining taken by prescription and with oversight from the accredited clinical Qualified.
Stay clear of or substitute another drug for these medications when achievable. Examine for loss of therapeutic effect if medication has to be coadministered.
Whilst specified medicines should not be utilised collectively in the slightest degree, in other scenarios two diverse medicines could possibly be employed together whether or not an interaction may possibly occur. In these instances, your physician will want to change the dose, or other safeguards may very well be needed.
Liver sickness, serious—Use with caution. You might require a dose adjustment. Talk with your health practitioner In case you have issues relating to this.
Observe Carefully (1)modafinil raises amounts of eluxadoline by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Monitor. To be a precautionary evaluate due to incomplete information on the metabolism of eluxadoline, use caution when coadministered with robust CYP2C19 inhibitors.
Doses nearly four hundred mg/working day, supplied as just one dose, are perfectly tolerated, but there's no reliable proof this dose confers extra reward over and above that on the two hundred mg/day dose
mitotane decreases levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Mitotane is a solid inducer check here of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for achievable dosage adjustments.
In keeping with an observational study of 11 men and women on opioid drugs, modafinil reportedly minimized sleepiness without the need of disrupting the members’ rest styles.
While this may possibly seem to be good news, it ought to be noted that this research was fairly quick, and only lasted 16 weeks — so it’s entirely feasible there are subtler, extra lengthy-lasting hazards that were not observed by this examine style and design.
It is not regarded irrespective of whether this drugs will hurt an unborn little one. Notify your medical doctor For anyone who is Expecting or plan to become pregnant.
nevirapine will minimize the extent or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Even so, this only means that it is comparatively safer than other medication: it does not imply that modafinil is totally with out hazards.